Pathway retrofitting yields insights into the biosynthesis of anthraquinone-fused enediynes

• المؤلفون الرئيسيون: Ma, Guang-Lei, Tran, Hoa Thi, Low, Zhen Jie, Candra, Hartono, Pang, Li Mei, Cheang, Qing Wei, Fang, Mingliang, Liang, Zhao-Xun
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Medicine, Health and Life Sciences; Biosynthesis; Natural Product; Enzyme; Synthetic Biology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/155780
• المؤسسة: Nanyang Technological University

Anthraquinone-fused enediynes (AQEs) are renowned for their distinctive molecular architecture, reactive enediyne warhead, and potent anticancer activity. Although the first members of AQEs, i.e., dynemicins, were discovered three decades ago, how their nitrogen-containing carbon skeleton is sy...