Guiding transition metal-doped hollow cerium tandem nanozymes with elaborately regulated multi-enzymatic activities for intensive chemodynamic therapy

• Main Authors: Dong, Shuming, Dong, Yushan, Liu, Bin, Liu, Jing, Liu, Shikai, Zhao, Zhiyu, Li, Wenting, Tian, Boshi, Zhao, Ruoxi, He, Fei, Gai, Shili, Xie, Ying, Yang, Piaoping, Zhao, Yanli
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Cancer Treatment; Chemodynamic Therapy
• Online Access: https://hdl.handle.net/10356/155940
• Institution: Nanyang Technological University

Clinical applications of nanozyme-initiated chemodynamic therapy (NCDT) have been severely limited by poor catalytic efficiency of nanozymes, insufficient endogenous H2O2 content, and off-target consumption. Herein, we develop hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with el...