Discovery of hyperstable noncanonical plant-derived epidermal growth factor receptor agonist and analogs

• Main Authors: Loo, Shining, Kam, Antony, Li, Binbin, Feng, Nan, Wang, Xiaoliang, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences::Biochemistry; Science::Medicine; Amino Acid Motifs; Epidermal Growth Factor Receptor
• Online Access: https://hdl.handle.net/10356/156118
• Institution: Nanyang Technological University

Here, we report the discovery of the first plant- derived and noncanonical epidermal growth factor receptor (EGFR) agonist, the 36-residue bleogen pB1 from Pereskia bleo of the Cactaceae family. We show that bleogen pB1 is a low-affinity EGFR agonist using a suite of chemical, biochemical, cellu...