Discovery of hyperstable noncanonical plant-derived epidermal growth factor receptor agonist and analogs
Here, we report the discovery of the first plant- derived and noncanonical epidermal growth factor receptor (EGFR) agonist, the 36-residue bleogen pB1 from Pereskia bleo of the Cactaceae family. We show that bleogen pB1 is a low-affinity EGFR agonist using a suite of chemical, biochemical, cellu...
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Main Authors: | Loo, Shining, Kam, Antony, Li, Binbin, Feng, Nan, Wang, Xiaoliang, Tam, James P. |
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Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2022
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/156118 |
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Institution: | Nanyang Technological University |
Language: | English |
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