Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib

• Main Authors: Kannan, S, Pradhan, M.R, Tiwari, G, Tan, W.-C, Chowbay, B, Tan, E.H, Tan, D.S.-W, Verma, C
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: afatinib; epidermal growth factor receptor; ligand; water; antagonists and inhibitors; binding site; chemistry; enzyme activation; genetics; human; molecular dynamics; mutation; Afatinib; Binding Sites; Enzyme Activation; ErbB Receptors; Humans; Ligands; Molecular Dynamics Simulation; Mutation; Water
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175187
• Institution: National University of Singapore

10.1038/s41598-017-01491-z