Use of the Z-DNA binding domain of ADAR1 as a probe for nucleic acids in left-handed conformation

• Main Author: Li, Heng
• Other Authors: Peter Droge
• Format: Theses and Dissertations
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Deoxyribonucleic acids
• Online Access: https://hdl.handle.net/10356/15657
• Institution: Nanyang Technological University

Both DNA and RNA can be in Z-conformation. Compared to classical B-DNA conformation, Z-DNA is in a higher energy state and studied extensively, so far mainly in vitro. It has been recognized that Z-DNA plays roles in many biological activities, including regulation of transcription, chromatin remode...