Albumin-based therapeutics capable of glutathione consumption and hydrogen peroxide generation for synergetic chemodynamic and chemotherapy of cancer

• Main Authors: Yang, Guangbao, Wang, Dongdong, Phua, Fiona Soo Zeng, Bindra, Anivind Kaur, Qian, Cheng, Zheng, Rui, Cheng, Liang, Liu, Guofeng, Wu, Hongwei, Liu, Zhuang, Zhao, Yanli
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Chemistry; Chemodynamic Therapy; Chemotherapy
• 在線閱讀: https://hdl.handle.net/10356/156675
• 機構: Nanyang Technological University

A nanoscale therapeutic system with good biocompatibility was facilely fabricated by the coassembly of human serum albumin and glucose oxidase (GOD), where the former was pretreated with metal ions through a chelating agent or the chemotherapeutic prodrug oxaliplatin (Oxa(IV)). Among different chela...