Chaperone-mediated formation of shell-like TDP-43 condensates

• Main Author: Kong, Jian Hua
• Other Authors: Choe Young Jun
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2022
• Subjects: Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/156869
• Institution: Nanyang Technological University

Transactivation response element DNA binding protein 43 (TDP-43), an RNA-binding protein is the major component of inclusion bodies in patients afflicted with Amyotrophic Lateral Sclerosis (ALS). A recent study established that a compromise in RNA-binding capacity of TDP-43, resulting from post-tra...