Hydrophosphination as a valuable tool to chiral diphosphines and their derivatives

Chiral diphosphine ligands are a ubiquitous class of privileged ligand which finds extensive application in transition metal catalysis and biochemistry. This thesis explores the development of a new methodology of accessing P-chiral diphosphine ligands with high to excellent enantioselectivities and...

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Main Author: Teo, Ronald Hong Xiang
Other Authors: Leung Pak Hing
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2022
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Online Access:https://hdl.handle.net/10356/157038
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1570382023-03-01T00:01:26Z Hydrophosphination as a valuable tool to chiral diphosphines and their derivatives Teo, Ronald Hong Xiang Leung Pak Hing Pullarkat Appukuttan Sumod School of Physical and Mathematical Sciences pakhing@ntu.edu.sg, Sumod@ntu.edu.sg Science::Chemistry Chiral diphosphine ligands are a ubiquitous class of privileged ligand which finds extensive application in transition metal catalysis and biochemistry. This thesis explores the development of a new methodology of accessing P-chiral diphosphine ligands with high to excellent enantioselectivities and moderate diastereoselectivities. Next, the synthesis of C-chiral diphosphines from naturally occurring curcumin and derivatives was attempted and the cytotoxicity of the diphosphine metal complexes was evaluated and compared against cisplatin and curcumin in the MKN74 and MCF7 cancer cell-lines. Lastly, the challenges associated with the generation of chiral phosphine-phosphino-chalcogenide and their complexes were discussed in detail and an example of the catalytic property of the phosphine-phosphino-chalcogenide metal complexes was illustrated. Doctor of Philosophy 2022-05-04T23:46:52Z 2022-05-04T23:46:52Z 2021 Thesis-Doctor of Philosophy Teo, R. H. X. (2021). Hydrophosphination as a valuable tool to chiral diphosphines and their derivatives. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/157038 https://hdl.handle.net/10356/157038 10.32657/10356/157038 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
spellingShingle Science::Chemistry
Teo, Ronald Hong Xiang
Hydrophosphination as a valuable tool to chiral diphosphines and their derivatives
description Chiral diphosphine ligands are a ubiquitous class of privileged ligand which finds extensive application in transition metal catalysis and biochemistry. This thesis explores the development of a new methodology of accessing P-chiral diphosphine ligands with high to excellent enantioselectivities and moderate diastereoselectivities. Next, the synthesis of C-chiral diphosphines from naturally occurring curcumin and derivatives was attempted and the cytotoxicity of the diphosphine metal complexes was evaluated and compared against cisplatin and curcumin in the MKN74 and MCF7 cancer cell-lines. Lastly, the challenges associated with the generation of chiral phosphine-phosphino-chalcogenide and their complexes were discussed in detail and an example of the catalytic property of the phosphine-phosphino-chalcogenide metal complexes was illustrated.
author2 Leung Pak Hing
author_facet Leung Pak Hing
Teo, Ronald Hong Xiang
format Thesis-Doctor of Philosophy
author Teo, Ronald Hong Xiang
author_sort Teo, Ronald Hong Xiang
title Hydrophosphination as a valuable tool to chiral diphosphines and their derivatives
title_short Hydrophosphination as a valuable tool to chiral diphosphines and their derivatives
title_full Hydrophosphination as a valuable tool to chiral diphosphines and their derivatives
title_fullStr Hydrophosphination as a valuable tool to chiral diphosphines and their derivatives
title_full_unstemmed Hydrophosphination as a valuable tool to chiral diphosphines and their derivatives
title_sort hydrophosphination as a valuable tool to chiral diphosphines and their derivatives
publisher Nanyang Technological University
publishDate 2022
url https://hdl.handle.net/10356/157038
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