Interdomain flexibility of Chikungunya virus nsP2 helicase-protease differentially influences viral RNA replication and infectivity

• Main Authors: Law, Yee-Song, Wang, Sainan, Tan, Yaw Bia, Shih, Orion, Utt, Age, Goh, Wei Yang, Lian, Bing-Jun, Chen, Ming Wei, Jeng, U-Ser, Merits, Andres, Luo, Dahai
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Alphavirus; Nonstructural Protein 2
• Online Access: https://hdl.handle.net/10356/157045
• Institution: Nanyang Technological University

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which has both nucleotide triphosphatase and RNA triphosphatase activities...