Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1

• Main Authors: Zhang, Kuo, Law, Yee-Song, Law, Michelle Cheok Yien, Tan, Yaw Bia, Wirawan, Melissa, Luo, Dahai
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Chikungunya Virus; RNA Cap
• Online Access: https://hdl.handle.net/10356/157046
• Institution: Nanyang Technological University

Chikungunya virus (CHIKV) causes a debilitating arthralgic inflammatory disease in humans. The multifunctional CHIKV protein, nsP1, facilitates virus RNA replication and transcription by anchoring the viral replication complex (RC) to plasma membrane vesicles and synthesizing the viral RNA 5' c...