Molecular basis of specific viral RNA recognition and 5'-end capping by the Chikungunya virus nsP1

• Main Authors: Zhang, Kuo, Law, Michelle Cheok Yien, Nguyen, Trinh Mai, Tan, Yaw Bia, Wirawan, Melissa, Law, Yee-Song, Jeong, Lak Shin, Luo, Dahai
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Science::Biological sciences; mRNA; Chikungunya Virus
• Online Access: https://hdl.handle.net/10356/164882
• Institution: Nanyang Technological University

Many viruses encode RNA-modifying enzymes to edit the 5' end of viral RNA to mimic the cellular mRNA for effective protein translation, genome replication, and evasion of the host defense mechanisms. Alphavirus nsP1 synthesizes the 5' end Cap-0 structure of viral RNAs. However, the molecul...