Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

• Main Authors: Ma, Jiajia, Scott, Claire A., Ho, Ying Na, Mahabaleshwar, Harsha, Marsay, Katherine S., Zhang, Changqing, Teow, Christopher K. J., Ng, Ser Sue, Zhang, Weibin, Tergaonkar, Vinay, Partridge, Lynda J., Roy, Sudipto, Amaya, Enrique, Carney, Tom J.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Epidermis; Epithelia
• Online Access: https://hdl.handle.net/10356/159382
• Institution: Nanyang Technological University

Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such responses are also elicited upon overexpression of the membrane-bound protease, Matriptase, or mutation of its inhibitor, Hai1. Unrestricted Matriptase activity also predisposes to...