Quantitative structure-retention relationship for reliable metabolite identification and quantification in metabolomics using ion-pair reversed-phase chromatography coupled with tandem mass spectrometry

• المؤلفون الرئيسيون: Hu, Qingyu, Sun, Yuting, Yuan, Peihong, Lei, Hehua, Zhong, Huiqin, Wang, Yulan, Tang, Huiru
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Medicine; UHPLC-MS; Metabolomics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/159581

Hydrophilic metabolites are essential for all biological systems with multiple functions and their quantitative analysis forms an important part of metabolomics. However, poor retention of these metabolites on reversed-phase (RP) chromatographic column hinders their effective analysis with RPLC-MS m...