Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions

• Main Authors: Lu, Beibei, Bo, Yiyang, Yi, Mingjie, Wang, Zhenyuan, Zhang, Jichuan, Zhu, Zhenye, Zhao, Yanli, Zhang, Jiaheng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Density Functional Theory; Drug Solubility
• Online Access: https://hdl.handle.net/10356/159672
• Institution: Nanyang Technological University

The development of hydrophobic drug and protein delivery carriers remains a challenge. To synthesize L-(-)-carnitine-based ionic liquid (IL), this study applies the density functional theory to investigate the hydrogen bonds and van der Waals force that govern L-(-)-carnitine-based IL formation. An...