Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions

The development of hydrophobic drug and protein delivery carriers remains a challenge. To synthesize L-(-)-carnitine-based ionic liquid (IL), this study applies the density functional theory to investigate the hydrogen bonds and van der Waals force that govern L-(-)-carnitine-based IL formation. An...

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Main Authors: Lu, Beibei, Bo, Yiyang, Yi, Mingjie, Wang, Zhenyuan, Zhang, Jichuan, Zhu, Zhenye, Zhao, Yanli, Zhang, Jiaheng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/159672
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1596722022-06-29T07:11:21Z Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions Lu, Beibei Bo, Yiyang Yi, Mingjie Wang, Zhenyuan Zhang, Jichuan Zhu, Zhenye Zhao, Yanli Zhang, Jiaheng School of Physical and Mathematical Sciences Science::Chemistry Density Functional Theory Drug Solubility The development of hydrophobic drug and protein delivery carriers remains a challenge. To synthesize L-(-)-carnitine-based ionic liquid (IL), this study applies the density functional theory to investigate the hydrogen bonds and van der Waals force that govern L-(-)-carnitine-based IL formation. An ionic liquid-in-oil microemulsion (IL/O ME) is then developed to facilitate the transdermal delivery of proteins and increase the solubility of drugs. IL/O ME is prepared using isopropyl myristate (IPM), Tween 80/Span 20, and L-(-)-carnitine-based IL. The skin permeation studies conducted using mouse skin show that the insulin permeation percentage of the developed IL/O ME is 3.55 folds higher than that of phosphate-buffered saline and 2.91 folds better than that of a hydrophilic L-(-)-carnitine-based IL. In addition, the solubility of two drug molecules, that is, rosiglitazone and bezafibrate, in IL/O ME is at least 49.28 folds higher than their solubility in water or IPM. Therefore, IL/O ME can significantly improve the solubility of drugs and increase the permeability of proteins (e.g., insulin), thus demonstrating a promising potential as a delivery carrier. National Research Foundation (NRF) Singapore Advanced Research & Education Network (SingAREN) This work was supported by the National Natural Science Foundation of China (21703218), the Shenzhen Science and Technology Innovation Committee (JCYJ20180507183907224 and KQTD20170809110344233), the Economic, Trade, and Information Commission of Shenzhen Municipality through the Graphene Manufacture Innovation Center (201901161514), the Guangdong Province Covid-19 Pandemic Control Research Fund (2020KZDZX1220), and the China Scholarship Council (202006120444). This work was partially supported by the Singapore Academic Research Fund (RT12/19) and the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03). 2022-06-29T07:11:21Z 2022-06-29T07:11:21Z 2021 Journal Article Lu, B., Bo, Y., Yi, M., Wang, Z., Zhang, J., Zhu, Z., Zhao, Y. & Zhang, J. (2021). Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions. Advanced Functional Materials, 31(34), 2102794-. https://dx.doi.org/10.1002/adfm.202102794 1616-301X https://hdl.handle.net/10356/159672 10.1002/adfm.202102794 2-s2.0-85107918532 34 31 2102794 en RT12/19 NRF-NRFI2018-03 Advanced Functional Materials © 2021 Wiley-VCH GmbH. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Density Functional Theory
Drug Solubility
spellingShingle Science::Chemistry
Density Functional Theory
Drug Solubility
Lu, Beibei
Bo, Yiyang
Yi, Mingjie
Wang, Zhenyuan
Zhang, Jichuan
Zhu, Zhenye
Zhao, Yanli
Zhang, Jiaheng
Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions
description The development of hydrophobic drug and protein delivery carriers remains a challenge. To synthesize L-(-)-carnitine-based ionic liquid (IL), this study applies the density functional theory to investigate the hydrogen bonds and van der Waals force that govern L-(-)-carnitine-based IL formation. An ionic liquid-in-oil microemulsion (IL/O ME) is then developed to facilitate the transdermal delivery of proteins and increase the solubility of drugs. IL/O ME is prepared using isopropyl myristate (IPM), Tween 80/Span 20, and L-(-)-carnitine-based IL. The skin permeation studies conducted using mouse skin show that the insulin permeation percentage of the developed IL/O ME is 3.55 folds higher than that of phosphate-buffered saline and 2.91 folds better than that of a hydrophilic L-(-)-carnitine-based IL. In addition, the solubility of two drug molecules, that is, rosiglitazone and bezafibrate, in IL/O ME is at least 49.28 folds higher than their solubility in water or IPM. Therefore, IL/O ME can significantly improve the solubility of drugs and increase the permeability of proteins (e.g., insulin), thus demonstrating a promising potential as a delivery carrier.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Lu, Beibei
Bo, Yiyang
Yi, Mingjie
Wang, Zhenyuan
Zhang, Jichuan
Zhu, Zhenye
Zhao, Yanli
Zhang, Jiaheng
format Article
author Lu, Beibei
Bo, Yiyang
Yi, Mingjie
Wang, Zhenyuan
Zhang, Jichuan
Zhu, Zhenye
Zhao, Yanli
Zhang, Jiaheng
author_sort Lu, Beibei
title Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions
title_short Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions
title_full Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions
title_fullStr Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions
title_full_unstemmed Enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions
title_sort enhancing the solubility and transdermal delivery of drugs using ionic liquid-in-oil microemulsions
publishDate 2022
url https://hdl.handle.net/10356/159672
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