A PDZ protein GIPC3 positively modulates hedgehog signaling and melanoma growth
The hedgehog (Hh) pathway is essential for animal development, but aberrant activation promotes cancer growth. In this study, we show that GIPC3, a PDZ domain-containing protein with putative adaptor protein function, positively modulates Hh target gene expression in normal fibroblasts and melanoma...
Saved in:
Main Authors: | Patmanathan, Sathya Narayanan, Tong, Bing Teck, Teo, Jackie Jia Hao, Ting, Jonathan Yong Zheng, Tan, Nguan Soon, Sim, Kenice Siew Hoon, Ta, Yng-Cun, Woo, Wei-Meng |
---|---|
其他作者: | Lee Kong Chian School of Medicine (LKCMedicine) |
格式: | Article |
語言: | English |
出版: |
2022
|
主題: | |
在線閱讀: | https://hdl.handle.net/10356/159770 |
標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|
機構: | Nanyang Technological University |
語言: | English |
相似書籍
-
Regulation of primary cilia formation and hedgehog signalling by a PDZ domain protein with function in melanoma growth
由: Teo, Jackie Jia Hao
出版: (2020) -
INVESTIGATIONS ON THE ROLE OF RAB23 ON CORTICOGENESIS IN THE MOUSE
由: HEIDI SHIOW CHYONG LIOU
出版: (2015) -
A ternary complex comprising transportin1, Rab8 and the ciliary targeting signal directs proteins to ciliary membranes
由: Madugula, Viswanadh, et al.
出版: (2017) -
IDENTIFICATION AND CHARACTERIZATION OF FOXJ1-INDUCED GENES IN MOTILE CILIA
由: DEEPAK BABU
出版: (2016) -
Identification of important effector proteins in the FOXJ1 transcriptional network associated with ciliogenesis and ciliary function
由: Mukherjee, I., et al.
出版: (2022)