A novel mechanism of monoethylhexyl phthalate in lipid accumulation via inhibiting fatty acid beta-oxidation on hepatic cells

• Main Authors: Xu, Tengfei, Lim, Yan Ting, Chen, Liyan, Zhao, Haoduo, Low, Jian Hui, Xia, Yun, Sobota, Radoslaw Mikolaj, Fang, Mingliang
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Environmental engineering; Target; Metabolites
• Online Access: https://hdl.handle.net/10356/159778
• Institution: Nanyang Technological University

Monoethylhexyl phthalate (MEHP) is one of the main active metabolites of the plasticizer di(2-ethylhexyl) phthalate. It has been known that MEHP has an impact on lipolysis; however, its mechanism on the cellular lipid metabolism remains largely unclear. Here, we first utilized global lipid profiling...