Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides
Global rise of infections and deaths caused by drug-resistant bacterial pathogens are among the unmet medical needs. In an age of drying pipeline of novel antibiotics to treat bacterial infections, antimicrobial peptides (AMPs) are proven to be valid therapeutics modalities. Direct in vivo applicati...
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sg-ntu-dr.10356-1601912023-02-28T17:11:47Z Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides Bhattacharjya, Surajit Mohid, Sk Abdul Bhunia, Anirban School of Biological Sciences Science::Biological sciences Antibiotics Multidrug Resistant Bacteria Global rise of infections and deaths caused by drug-resistant bacterial pathogens are among the unmet medical needs. In an age of drying pipeline of novel antibiotics to treat bacterial infections, antimicrobial peptides (AMPs) are proven to be valid therapeutics modalities. Direct in vivo applications of many AMPs could be challenging; however, works are demonstrating encouraging results for some of them. In this review article, we discussed 3-D structures of potent AMPs e.g., polymyxin, thanatin, MSI, protegrin, OMPTA in complex with bacterial targets and their mode of actions. Studies on human peptide LL37 and de novo-designed peptides are also discussed. We have focused on AMPs which are effective against drug-resistant Gram-negative bacteria. Since treatment options for the infections caused by super bugs of Gram-negative bacteria are now extremely limited. We also summarize some of the pertinent challenges in the field of clinical trials of AMPs. Ministry of Education (MOE) Published version S.B. acknowledges funding from Ministry of Education (MOE) and Biomedical Research Council (BMRC), Singapore. This research was partly supported by Science and Engineering Research Board, Govt. of India (File No. EMR/2017/003457 to AB). 2022-07-14T07:08:50Z 2022-07-14T07:08:50Z 2022 Journal Article Bhattacharjya, S., Mohid, S. A. & Bhunia, A. (2022). Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides. International Journal of Molecular Sciences, 23(9), 4558-. https://dx.doi.org/10.3390/ijms23094558 1661-6596 https://hdl.handle.net/10356/160191 10.3390/ijms23094558 35562950 2-s2.0-85128416126 9 23 4558 en International Journal of Molecular Sciences © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
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Science::Biological sciences Antibiotics Multidrug Resistant Bacteria Bhattacharjya, Surajit Mohid, Sk Abdul Bhunia, Anirban Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides |
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Global rise of infections and deaths caused by drug-resistant bacterial pathogens are among the unmet medical needs. In an age of drying pipeline of novel antibiotics to treat bacterial infections, antimicrobial peptides (AMPs) are proven to be valid therapeutics modalities. Direct in vivo applications of many AMPs could be challenging; however, works are demonstrating encouraging results for some of them. In this review article, we discussed 3-D structures of potent AMPs e.g., polymyxin, thanatin, MSI, protegrin, OMPTA in complex with bacterial targets and their mode of actions. Studies on human peptide LL37 and de novo-designed peptides are also discussed. We have focused on AMPs which are effective against drug-resistant Gram-negative bacteria. Since treatment options for the infections caused by super bugs of Gram-negative bacteria are now extremely limited. We also summarize some of the pertinent challenges in the field of clinical trials of AMPs. |
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School of Biological Sciences |
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School of Biological Sciences Bhattacharjya, Surajit Mohid, Sk Abdul Bhunia, Anirban |
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Article |
author |
Bhattacharjya, Surajit Mohid, Sk Abdul Bhunia, Anirban |
author_sort |
Bhattacharjya, Surajit |
title |
Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides |
title_short |
Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides |
title_full |
Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides |
title_fullStr |
Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides |
title_full_unstemmed |
Atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides |
title_sort |
atomic-resolution structures and mode of action of clinically relevant antimicrobial peptides |
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2022 |
url |
https://hdl.handle.net/10356/160191 |
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1759853878415720448 |