WNK3 maintains the GABAergic inhibitory tone, synaptic excitation and neuronal excitability via regulation of KCC2 cotransporter in mature neurons

• Main Authors: Lim, Wee Meng, Chin, Eunice W. M., Tang, Bor Luen, Chen, Tingting, Goh, Eyleen Lay Keow
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; GABAergic Inhibitory Tone; Synaptic Excitation
• Online Access: https://hdl.handle.net/10356/160211
• Institution: Nanyang Technological University

The activation of chloride (Cl-)permeable gamma (γ)-aminobutyric acid type A(GABAA) receptors induces synaptic inhibition in mature and excitation in immature neurons. This developmental "switch" in GABA function controlled by its polarity depends on the postnatal decrease in intraneuronal...