Visible-light-induced trifluoromethylation of allylic alcohols

Visible-light-induced trifluoromethylation of allylic alcohols

An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activat...

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Bibliographic Details
Main Authors: Li, Bowen, Zeng, Wubing, Wang, Lin, Geng, Zhishuai, Loh, Teck-Peng, Xie, Peizhong
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Copper-Catalyzed Trifluoromethylation
Alkenes
Online Access:https://hdl.handle.net/10356/160359
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Institution: Nanyang Technological University
Language: English
Description
Summary:An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activate C-OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF3-allylic compounds were obtained in high yields and excellent stereoselectivity.

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