Visible-light-induced trifluoromethylation of allylic alcohols
An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activat...
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sg-ntu-dr.10356-1603592022-07-20T01:45:39Z Visible-light-induced trifluoromethylation of allylic alcohols Li, Bowen Zeng, Wubing Wang, Lin Geng, Zhishuai Loh, Teck-Peng Xie, Peizhong School of Physical and Mathematical Sciences Science::Chemistry Copper-Catalyzed Trifluoromethylation Alkenes An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activate C-OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF3-allylic compounds were obtained in high yields and excellent stereoselectivity. We gratefully acknowledge financial support from the National Natural Science Foundation of China (21702108), the Natural Science Foundation of Jiangsu Province, China (BK20160977), and the Six Talent Peaks Project in Jiangsu Province (YY-033). 2022-07-20T01:45:39Z 2022-07-20T01:45:39Z 2021 Journal Article Li, B., Zeng, W., Wang, L., Geng, Z., Loh, T. & Xie, P. (2021). Visible-light-induced trifluoromethylation of allylic alcohols. Organic Letters, 23(13), 5235-5240. https://dx.doi.org/10.1021/acs.orglett.1c01767 1523-7060 https://hdl.handle.net/10356/160359 10.1021/acs.orglett.1c01767 34156254 2-s2.0-85110301148 13 23 5235 5240 en Organic Letters © 2021 American Chemical Society. All rights reserved. |
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Science::Chemistry Copper-Catalyzed Trifluoromethylation Alkenes |
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Science::Chemistry Copper-Catalyzed Trifluoromethylation Alkenes Li, Bowen Zeng, Wubing Wang, Lin Geng, Zhishuai Loh, Teck-Peng Xie, Peizhong Visible-light-induced trifluoromethylation of allylic alcohols |
| description |
An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activate C-OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF3-allylic compounds were obtained in high yields and excellent stereoselectivity. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Li, Bowen Zeng, Wubing Wang, Lin Geng, Zhishuai Loh, Teck-Peng Xie, Peizhong |
| format |
Article |
| author |
Li, Bowen Zeng, Wubing Wang, Lin Geng, Zhishuai Loh, Teck-Peng Xie, Peizhong |
| author_sort |
Li, Bowen |
| title |
Visible-light-induced trifluoromethylation of allylic alcohols |
| title_short |
Visible-light-induced trifluoromethylation of allylic alcohols |
| title_full |
Visible-light-induced trifluoromethylation of allylic alcohols |
| title_fullStr |
Visible-light-induced trifluoromethylation of allylic alcohols |
| title_full_unstemmed |
Visible-light-induced trifluoromethylation of allylic alcohols |
| title_sort |
visible-light-induced trifluoromethylation of allylic alcohols |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/160359 |
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1739837368770232320 |