Desymmetrization of cyclic 1,3-Diketones under N-Heterocyclic carbene organocatalysis: access to organofluorines with multiple stereogenic centers

• المؤلفون الرئيسيون: Wang, Guanjie, Zhang, Min, Guan, Yezhi, Zhang, Ye, Hong, Xianfang, Wei, Chenlong, Zheng, Pengcheng, Wei, Donghui, Fu, Zhenqian, Chi, Robin Yonggui, Huang, Wei
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Chemistry; Anti-Bacterial Activity; Diastereoselectivities
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/160692

Symmetric 1,3-diketones with fluorine or fluorinated substituents on the prochiral carbon remain to be established. Herein, we have developed a novel prochiral fluorinated oxindanyl 1,3-diketone and successfully applied these substrates in carbene-catalyzed asymmetric desymmetrization. Accordingly,...