Desymmetrization of cyclic 1,3-Diketones under N-Heterocyclic carbene organocatalysis: access to organofluorines with multiple stereogenic centers

• Main Authors: Wang, Guanjie, Zhang, Min, Guan, Yezhi, Zhang, Ye, Hong, Xianfang, Wei, Chenlong, Zheng, Pengcheng, Wei, Donghui, Fu, Zhenqian, Chi, Robin Yonggui, Huang, Wei
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Science::Chemistry; Anti-Bacterial Activity; Diastereoselectivities
• 在線閱讀: https://hdl.handle.net/10356/160692
• 機構: Nanyang Technological University

Symmetric 1,3-diketones with fluorine or fluorinated substituents on the prochiral carbon remain to be established. Herein, we have developed a novel prochiral fluorinated oxindanyl 1,3-diketone and successfully applied these substrates in carbene-catalyzed asymmetric desymmetrization. Accordingly,...