APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups

• Main Authors: Goyal, Shiwali, Tanigawa, Yosuke, Zhang, Weihua, Chai, Jin-Fang, Almeida, Marcio, Sim, Xueling, Lerner, Megan, Chainakul, Juliane, Ramiu, Jonathan Garcia, Seraphin, Chanel, Apple, Blair, Vaughan, April, Muniu, James, Peralta, Juan, Lehman, Donna M., Ralhan, Sarju, Wander, Gurpreet S., Singh, Jai Rup, Mehra, Narinder K., Sidorov, Evgeny, Peyton, Marvin D., Blackett, Piers R., Curran, Joanne E., Tai, E Shyong, van Dam, Rob, Cheng, Ching-Yu, Duggirala, Ravindranath, Blangero, John, Chambers, John Campbell, Sabanayagam, Charumathi, Kooner, Jaspal S., Rivas, Manuel A., Aston, Christopher E., Sanghera, Dharambir K.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Mendelian Randomization; Asian Indians
• Online Access: https://hdl.handle.net/10356/160735
• Institution: Nanyang Technological University

Background: Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are cardioprotective in American Indians and Europeans. However, there is a lack of d...