HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

• Main Authors: Ho, Jessica S. Y., Di Tullio, Federico, Schwarz, Megan, Low, Diana, Incarnato, Danny, Gay, Florence, Tabaglio, Tommaso, Zhang, Jingxian, Wollmann, Heike, Chen, Leilei, An, Omer, Chan, Tim Hon Man, Hickman, Alexander Hall, Zheng, Simin, Roudko, Vladimir, Chen, Sujun, Karz, Alcida, Ahmed, Musaddeque, He, Hansen Housheng, Greenbaum, Benjamin D., Oliviero, Salvatore, Serresi, Michela, Gargiulo, Gaetano, Mann, Karen M., Hernando, Eva, Mulholland, David, Marazzi, Ivan, Wee, Dave Keng Boon, Guccione, Ernesto
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Circular Ribonucleic Acid; Animal Experiment
• Online Access: https://hdl.handle.net/10356/160757
• Institution: Nanyang Technological University

High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To identify splicing factors important for prostate cancer (PCa) fitness, we performed pooled shRNA screens in vitro and in vivo. Our screens id...