Can glycosylation mask the detection of MHC expressing p53 peptides by T cell receptors?

• Main Authors: Nguyen, Thanh Binh, Lane, David P., Verma, Chandra Shekhar
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Molecular Dynamics; Glycosylation
• Online Access: https://hdl.handle.net/10356/160817
• Institution: Nanyang Technological University

Proteins of the major histocompatibility complex (MHC) class I, or human leukocyte antigen (HLA) in humans interact with endogenous peptides and present them to T cell receptors (TCR), which in turn tune the immune system to recognize and discriminate between self and foreign (non-self) peptides. Of...