Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects

Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects

A minor alteration in structure of a previously reported synthetic K+ channel via replacing the electron-withdrawing group with an electron-donating group leads to enhancement in activity by 160% and in selectivity by >50%. As a result, the new K+ channel 10F5, despite having a simple structure,...

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Main Authors: Zeng, Landley Ziluo, Zhang, Hao, Wang, Tianxiang, Li, Tianhu
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Chemistry
Room-Temperature Gelation
Ion Channels
Online Access:https://hdl.handle.net/10356/160879
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1608792022-08-05T03:05:21Z Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects Zeng, Landley Ziluo Zhang, Hao Wang, Tianxiang Li, Tianhu School of Physical and Mathematical Sciences Science::Chemistry Room-Temperature Gelation Ion Channels A minor alteration in structure of a previously reported synthetic K+ channel via replacing the electron-withdrawing group with an electron-donating group leads to enhancement in activity by 160% and in selectivity by >50%. As a result, the new K+ channel 10F5, despite having a simple structure, exhibits a high K+/Na+ selectivity of 14.0. Agency for Science, Technology and Research (A*STAR) This work is funded by the Agency for Science, Technology and Research, Singapore (SERC A1883c0007 to T. L.). 2022-08-05T03:05:20Z 2022-08-05T03:05:20Z 2020 Journal Article Zeng, L. Z., Zhang, H., Wang, T. & Li, T. (2020). Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects. Chemical Communications, 56(8), 1211-1214. https://dx.doi.org/10.1039/C9CC08396K 1359-7345 https://hdl.handle.net/10356/160879 10.1039/C9CC08396K 8 56 1211 1214 en A1883c0007 Chemical Communications © 2020 The Royal Society of Chemistry. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Room-Temperature Gelation
Ion Channels
spellingShingle Science::Chemistry
Room-Temperature Gelation
Ion Channels
Zeng, Landley Ziluo
Zhang, Hao
Wang, Tianxiang
Li, Tianhu
Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects
description A minor alteration in structure of a previously reported synthetic K+ channel via replacing the electron-withdrawing group with an electron-donating group leads to enhancement in activity by 160% and in selectivity by >50%. As a result, the new K+ channel 10F5, despite having a simple structure, exhibits a high K+/Na+ selectivity of 14.0.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Zeng, Landley Ziluo
Zhang, Hao
Wang, Tianxiang
Li, Tianhu
format Article
author Zeng, Landley Ziluo
Zhang, Hao
Wang, Tianxiang
Li, Tianhu
author_sort Zeng, Landley Ziluo
title Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects
title_short Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects
title_full Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects
title_fullStr Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects
title_full_unstemmed Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects
title_sort enhancing k⁺ transport activity and selectivity of synthetic k⁺ channels via electron-donating effects
publishDate 2022
url https://hdl.handle.net/10356/160879
_version_ 1743119481027166208

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