Enhancing K⁺ transport activity and selectivity of synthetic K⁺ channels via electron-donating effects

• Main Authors: Zeng, Landley Ziluo, Zhang, Hao, Wang, Tianxiang, Li, Tianhu
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Room-Temperature Gelation; Ion Channels
• Online Access: https://hdl.handle.net/10356/160879
• Institution: Nanyang Technological University

A minor alteration in structure of a previously reported synthetic K+ channel via replacing the electron-withdrawing group with an electron-donating group leads to enhancement in activity by 160% and in selectivity by >50%. As a result, the new K+ channel 10F5, despite having a simple structure,...