Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease

• Main Authors: Selvan, Subramanian Tamil, Ravichandar, Roopa, Ghosh, Krishna Kanta, Mohan, A., Mahalakshmi, Pachaiyappan, Gulyás, Balázs, Padmanabhan, Parasuraman
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Alzheimer's Disease; Coordination Chemistry
• Online Access: https://hdl.handle.net/10356/161208
• Institution: Nanyang Technological University

The diagnosis and therapy of neurodegenerative diseases are highly indispensable. In particular, the definitive clinical diagnosis and therapy of Alzheimer's disease (AD) remains a challenge. Despite the use of amyloid beta (Aβ) positron emission tomography (PET) gold standard [11C]-PiB, other...