Roseltide rT7 is a disulfide-rich, anionic, and cell-penetrating peptide that inhibits proteasomal degradation

• Main Authors: Kam, Antony, Loo, Shining, Fan, Jing-Song, Sze, Siu Kwan, Yang, Daiwen, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Proteasome; Cell-Penetrating Peptide
• Online Access: https://hdl.handle.net/10356/161263
• Institution: Nanyang Technological University

Disulfide-rich plant peptides with molecular masses of 2-6 kDa represent an expanding class of peptidyl-type natural products with diverse functions. They are structurally compact, hyperstable, and underexplored as cell-penetrating agents that inhibit intracellular functions. Here, we report the dis...