A study of lipid-mediated clustering of oncogenic Ras proteins on cell membrane using nanotopography engineering

• المؤلف الرئيسي: Mu, Huanwen
• مؤلفون آخرون: Zhao Wenting
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2022
• الموضوعات: Engineering::Bioengineering
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/161320
• المؤسسة: Nanyang Technological University

Dysregulation of Ras, a dominant oncogenic protein, in cell proliferation, differentiation, and survival contributes to ~20% of human cancers. Despite great efforts paid in identifying anti-Ras therapeutics for the past decades, it remains a challenging task to provide effective anti-Ras drugs for c...