Mechanisms underlying C-type inactivation in Kv channels: lessons from structures of human Kv1.3 and fly shaker-IR channels

• Main Authors: Ong, Seow Theng, Tyagi, Anu, Chandy, Kanianthara George, Bhushan, Shashi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; C-Type Inactivation; Hydrogen Bond Network
• Online Access: https://hdl.handle.net/10356/161416
• Institution: Nanyang Technological University

Voltage-gated potassium (Kv) channels modulate the function of electrically-excitable and non-excitable cells by using several types of "gates" to regulate ion flow through the channels. An important gating mechanism, C-type inactivation, limits ion flow by transitioning Kv channels into a...