Targeted pancreatic beta cell imaging for early diagnosis
Pancreatic beta cells are important in blood glucose level regulation. As type 1 and 2 diabetes are getting prevalent worldwide, we need to explore new methods for early detection of beta cell-related afflictions. Using bioimaging techniques to measure beta cell mass is crucial because a decrease in...
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sg-ntu-dr.10356-1614392022-09-02T03:03:56Z Targeted pancreatic beta cell imaging for early diagnosis Cong, Goh Zheng Ghosh, Krishna Kanta Mishra, Sachin Gulyás, Miklós Kovács, Tibor Máthé, Domokos Padmanabhan, Parasuraman Gulyás, Balázs Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Diabetes Pancreatic Beta Cell Pancreatic beta cells are important in blood glucose level regulation. As type 1 and 2 diabetes are getting prevalent worldwide, we need to explore new methods for early detection of beta cell-related afflictions. Using bioimaging techniques to measure beta cell mass is crucial because a decrease in beta cell density is seen in diseases such as diabetes and thus can be a new way of diagnosis for such diseases. We also need to appraise beta cell purity in transplanted islets for type 1 diabetes patients. Sufficient amount of functional beta cells must also be determined before being transplanted to the patients. In this review, indirect imaging of beta cells will be discussed. This includes membrane protein on pancreatic beta cells whereby specific probes are designed for different imaging modalities mainly magnetic resonance imaging, positron emission tomography and fluorescence imaging. Direct imaging of insulin is also explored though probes synthesized for such function are relatively fewer. The path for successful pancreatic beta cell imaging is fraught with challenges like non-specific binding, lack of beta cell-restricted targets, the requirement of probes to cross multiple lipid layers to bind to intracellular insulin. Hence, there is an urgent need to develop new imaging techniques and innovative probing constructs in the entire imaging chain of bioengineering to provide early detection of beta cell-related pathology. Nanyang Technological University Authors acknowledge the support from Lee Kong Chian School of Medicine and NTU Austrian Institute of Technology and Medical University of Vienna internal Grant (NAM/15006) and LKCMedicine Imaging Probe Dev. Platform, Singapore. Authors also acknowledge the support from the Cognitive Neuroimaging Centre (CONIC) at Nanyang Technological University, Singapore. Tibor Kovacs acknowledges The Hungarian Government's Operative Programme of Economics and Innovation Support, Grant number GINOP-2.3.2-15-201. 2022-09-02T03:03:56Z 2022-09-02T03:03:56Z 2020 Journal Article Cong, G. Z., Ghosh, K. K., Mishra, S., Gulyás, M., Kovács, T., Máthé, D., Padmanabhan, P. & Gulyás, B. (2020). Targeted pancreatic beta cell imaging for early diagnosis. European Journal of Cell Biology, 99(7), 151110-. https://dx.doi.org/10.1016/j.ejcb.2020.151110 0171-9335 https://hdl.handle.net/10356/161439 10.1016/j.ejcb.2020.151110 33070042 2-s2.0-85089091388 7 99 151110 en European Journal of Cell Biology © 2020 Elsevier GmbH. All rights reserved. |
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Science::Medicine Diabetes Pancreatic Beta Cell Cong, Goh Zheng Ghosh, Krishna Kanta Mishra, Sachin Gulyás, Miklós Kovács, Tibor Máthé, Domokos Padmanabhan, Parasuraman Gulyás, Balázs Targeted pancreatic beta cell imaging for early diagnosis |
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Pancreatic beta cells are important in blood glucose level regulation. As type 1 and 2 diabetes are getting prevalent worldwide, we need to explore new methods for early detection of beta cell-related afflictions. Using bioimaging techniques to measure beta cell mass is crucial because a decrease in beta cell density is seen in diseases such as diabetes and thus can be a new way of diagnosis for such diseases. We also need to appraise beta cell purity in transplanted islets for type 1 diabetes patients. Sufficient amount of functional beta cells must also be determined before being transplanted to the patients. In this review, indirect imaging of beta cells will be discussed. This includes membrane protein on pancreatic beta cells whereby specific probes are designed for different imaging modalities mainly magnetic resonance imaging, positron emission tomography and fluorescence imaging. Direct imaging of insulin is also explored though probes synthesized for such function are relatively fewer. The path for successful pancreatic beta cell imaging is fraught with challenges like non-specific binding, lack of beta cell-restricted targets, the requirement of probes to cross multiple lipid layers to bind to intracellular insulin. Hence, there is an urgent need to develop new imaging techniques and innovative probing constructs in the entire imaging chain of bioengineering to provide early detection of beta cell-related pathology. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) Cong, Goh Zheng Ghosh, Krishna Kanta Mishra, Sachin Gulyás, Miklós Kovács, Tibor Máthé, Domokos Padmanabhan, Parasuraman Gulyás, Balázs |
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Article |
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Cong, Goh Zheng Ghosh, Krishna Kanta Mishra, Sachin Gulyás, Miklós Kovács, Tibor Máthé, Domokos Padmanabhan, Parasuraman Gulyás, Balázs |
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Cong, Goh Zheng |
title |
Targeted pancreatic beta cell imaging for early diagnosis |
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Targeted pancreatic beta cell imaging for early diagnosis |
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Targeted pancreatic beta cell imaging for early diagnosis |
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Targeted pancreatic beta cell imaging for early diagnosis |
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Targeted pancreatic beta cell imaging for early diagnosis |
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targeted pancreatic beta cell imaging for early diagnosis |
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2022 |
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https://hdl.handle.net/10356/161439 |
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1744365420287098880 |