Molecular phenotyping of single pancreatic islet leader beta cells by "Flash-Seq"

• Main Authors: Chabosseau, Pauline, Yong, Fiona, Delgadillo-Silva, Luis F., Lee, Eun Young, Melhem, Rana, Li, Shiying, Gandhi, Nidhi, Wastin, Jules, Noriega, Livia Lopez, Leclerc, Isabelle, Ali, Yusuf, Hughes, Jing W., Sladek, Robert, Martinez-Sanchez, Aida, Rutter, Guy A.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Diabetes; Beta Cell
• Online Access: https://hdl.handle.net/10356/171807
• Institution: Nanyang Technological University

Aims: Spatially-organized increases in cytosolic Ca2+ within pancreatic beta cells in the pancreatic islet underlie the stimulation of insulin secretion by high glucose. Recent data have revealed the existence of subpopulations of beta cells including “leaders” which initiate Ca2+ waves. Whether lea...