Amyloid β chaperone — lipocalin-type prostaglandin D synthase acts as a peroxidase in the presence of heme

• Main Authors: Phillips, Margaret, Kannaian, Bhuvaneswari, Ng, Justin Tze-Yang, Kather, Ralf, Mu, Yuguang, Harmer, Jeffrey R., Pervushin, Konstantin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Electron-Paramagnetic-Resonance; Site-Directed Mutagenesis
• Online Access: https://hdl.handle.net/10356/161448
• Institution: Nanyang Technological University

The extracellular transporter, lipocalin-type prostaglandin D synthase (L-PGDS) binds to heme and heme metabolites with high affinity. It has been reported that L-PGDS protects neuronal cells against apoptosis induced by exposure to hydrogen peroxide. Our study demonstrates that when human WT L-PGDS...