The promising immune checkpoint LAG-3 in cancer immunotherapy: from basic research to clinical application

• Main Authors: Huo, Jin-Ling, Wang, Ya-Tao, Fu, Wen-Jia, Lu, Nan, Liu, Zhang-Suo
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Mechanical engineering; LAG-3; Immune Checkpoint,
• Online Access: https://hdl.handle.net/10356/161477
• Institution: Nanyang Technological University

LAG-3, a type of immune checkpoint receptor protein belonging to the immunoglobulin superfamily, is confirmed to be expressed on activated immune cells, mainly including activated T cells. LAG-3 can negatively regulate the function of T cells, exerting important effects on maintaining the homeostasi...