Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma

• Main Authors: Chuah, Samuel, Lee, Joycelyn, Song, Yuan, Kim, Hyung-Don, Wasser, Martin, Kaya, Neslihan A., Bang, Kyunghye, Lee, Yong Joon, Jeon, Seung Hyuck, Suthen, Sheena, A'Azman, Shamirah, Gien, Gerald, Lim, Chun Jye, Chua, Camillus, Sharifah Nur Hazirah, Lee, Hong Kai, Lim, Jia Qi, Lim, Tony K. H., Yeong, Joe, Chen, Jinmiao, Shin, Eui-Cheol, Albani, Salvatore, Zhai, Weiwei, Yoo, Changhoon, Liu, Haiyan, Choo, Su Pin, Tai, David, Chew, Valerie
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Checkpoint Inhibitor; Immunoprofiling
• Online Access: https://hdl.handle.net/10356/162640
• Institution: Nanyang Technological University

Background & Aims: While immune checkpoint blockade (ICB) has shown promise in patients with hepatocellular carcinoma (HCC), it is associated with modest response rates and immune-related adverse events (irAEs) are common. In this study, we aimed to decipher immune trajectories and mechanisms of...