IRF-7 mediates type I IFN responses in endotoxin-challenged mice

by Sin, Wei-Xiang, Yeong, Joe Poh-Sheng, Lim, Thomas Jun Feng, Su, I-hsin, Connolly, John E., Chin, Keh-Chuang
Published 2020

Pan-cancer analysis connects tumor matrisome to immune response

by Lim, Su Bin, Chua, Melvin Lee Kiang, Yeong, Joe Poh Sheng, Jin, Swee Jin, Lim, Wan-Teck, Lim, Chwee Teck
Published 2022

The roles of CD38 and CD157 in the solid tumor microenvironment and cancer immunotherapy

by Wo, Yu Jun, Gan, Adelia Shin Ping, Lim, Xinru, Tay, Isabel Shu Ying, Lim, Sherlly, Lim, Jeffrey Chun Tatt, Yeong, Joe Poh Sheng
Published 2020

Epstein–Barr Virus Epithelial Cancers—A Comprehensive Understanding to Drive Novel Therapies

by Han, Shuting, Tay, Joshua K., Loh, Celestine Jia Ling, Chu, Axel Jun Ming, Yeong, Joe Poh Sheng, Lim, Chwee Ming, Toh, Han Chong
Published 2022

Clinical implications of systemic and local immune responses in human angiosarcoma

by Chan, Jason Yongsheng, Tan, Grace Fangmin, Yeong, Joe, Ong, Chee Wee, Ng, Dave Yong Xiang, Lee, Elizabeth, Koh, Joanna, Ng, Cedric Chuan-Young, Lee, Jing Yi, Liu, Wei, Wong, Ru Xin, Ong, Chin-Ann Johnny, Farid, Mohamad, Teh, Bin Tean, Soo, Khee Chee
Published 2022

Conditional knockout of hypoxia-inducible factor 1-alpha in tumor-infiltrating neutrophils protects against pancreatic ductal adenocarcinoma

by Sieow, Je Lin, Leong, Penny Hweixian, Gun, Sin Yee, Tan, Ling Qiao, Duan, Kaibo, Yeong, Joe Poh Sheng, Pang, Angela, Lim, Diana, Toh, Han Chong, Lim, Tony Kiat Hon, Engleman, Edgar, Rotzschke, Olaf, Ng, Lai Guan, Chen, Jinmiao, Tan, Suet Mien, Wong, Siew Cheng
Published 2023

Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma

by Sieow, Je Lin, Penny, Hweixian Leong, Gun, Sin Yee, Tan, Ling Qiao, Duan, Kaibo, Yeong, Joe Poh Sheng, Pang, Angela, Lim, Diana, Toh, Han Chong, Lim, Tony Kiat Hon, Engleman, Edgar, Rotzschke, Olaf, Ng, Lai Guan, Chen, Jinmao, Tan, Suet Mien, Wong, Siew Cheng
Published 2023

Transcriptional analysis highlights three distinct immune profiles of high-risk oral epithelial dysplasia

by Gan, Chai Phei, Lee, Bernard Kok Bang, Lau, Shin Hin, Kallarakkal, Thomas George, Zaini, Zuraiza Mohamad, Lye, Bryan Kit Weng, Zain, Rosnah Binti, Sathasivam, Hans Prakash, Yeong, Joe Poh Sheng, Savelyeva, Natalia, Thomas, Gareth, Ottensmeier, Christian H., Ariffin, Hany, Cheong, Sok Ching, Lim, Kue Peng
Published 2022

Successful targeting of PD-1/PD-L1 with chimeric antigen receptor-natural killer cells and nivolumab in a humanized mouse cancer model

by Liu, Wai Nam, So, Wing Yan, Harden, Sarah L, Fong, Shin Yie, Wong, Melissa Xin Yu, Tan, Wilson Wei Sheng, Tan, Sue Yee, Ong, Jessica Kai Lin, Rajarethinam, Ravisankar, Liu, Min, Cheng, Jia Ying, Suteja, Lisda, Yeong, Joe Poh Sheng, Iyer, N Gopalakrishna, Lim, Darren Wan-Teck, Chen, Qingfeng
Published 2024

Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma

by Lim, Darren Wan-Teck, Kao, Hsiang-Fong, Suteja, Lisda, Li, Constance H, Quah, Hong Sheng, Tan, Daniel Shao-Weng, Tan, Sze-Huey, Tan, Eng-Huat, Tan, Wan-Ling, Lee, Justina Nadia, Wee, Felicia Yu-Ting, Jain, Amit, Goh, Boon-Cher, Chua, Melvin LK, Liao, Bin-Chi, Ng, Quan Sing, Hong, Ruey-Long, Ang, Mei-Kim, Yeong, Joe Poh-Sheng, Iyer, N Gopalakrishna
Published 2024

Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer

by Hoppe, Michal M, Jaynes, Patrick, Wardyn, Joanna D, Upadhyayula, Sai Srinivas, Tan, Tuan Zea, Lie, Stefanus, Lim, Diana GZ, Pang, Brendan NK, Lim, Sherlly, P S Yeong, Joe, Karnezis, Anthony, Chiu, Derek S, Leung, Samuel, Huntsman, David G, Sedukhina, Anna S, Sato, Ko, Topp, Monique D, Scott, Clare L, Choi, Hyungwon, Patel, Naina R, Brown, Robert, Kaye, Stan B, Pitt, Jason J, Tan, David SP, Jeyasekharan, Anand D
Published 2021

Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma

by Chuah, Samuel, Lee, Joycelyn, Song, Yuan, Kim, Hyung-Don, Wasser, Martin, Kaya, Neslihan A., Bang, Kyunghye, Lee, Yong Joon, Jeon, Seung Hyuck, Suthen, Sheena, A'Azman, Shamirah, Gien, Gerald, Lim, Chun Jye, Chua, Camillus, Sharifah Nur Hazirah, Lee, Hong Kai, Lim, Jia Qi, Lim, Tony K. H., Yeong, Joe, Chen, Jinmiao, Shin, Eui-Cheol, Albani, Salvatore, Zhai, Weiwei, Yoo, Changhoon, Liu, Haiyan, Choo, Su Pin, Tai, David, Chew, Valerie
Published 2022

Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma

by Penny, Hweixian Leong, Sieow, Je Lin, Gun, Sin Yee, Lau, Mai Chan, Lee, Bernett, Tan, Jasmine, Phua, Cindy, Toh, Florida, Nga, Yvonne, Yeap, Wei Hseun, Janela, Baptiste, Kumar, Dilip, Chen, Hao, Yeong, Joe, Kenkel, Justin A, Pang, Angela, Lim, Diana, Toh, Han Chong, Hon, Tony Lim Kiat, Johnson, Christopher, Khameneh, Hanif Javanmard, Mortellaro, Alessandra, Engleman, Edgar G, Rotzschke, Olaf, Ginhoux, Florent, Abastado, Jean-Pierre, Chen, Jinmiao, Wong, Siew Cheng
Published 2021

Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis

by Tay, Sen Hee, Zharkova, Olga, Lee, Hui Yin, Toh, Michelle Min Xuan, Libau, Eshele Anak, Celhar, Teja, Narayanan, Sriram, Ahl, Patricia Jennifer, Ong, Wei Yee, Joseph, Craig, Lim, Jeffrey Chun Tatt, Wang, Lingzhi, Larbi, Anis, Liang, Shen, Lateef, Aisha, Akira, Shizuo, Ling, Lieng Hsi, Thamboo, Thomas Paulraj, Yeong, Joe Poh Seng, Lee, Bernett Teck Kwong, Edwards, Steven W, Wright, Helen L, MacAry, Paul Anthony, Connolly, John E, Fairhurst, Anna-Marie
Published 2024

Multi-center evaluation of artificial intelligent imaging and clinical models for predicting neoadjuvant chemotherapy response in breast cancer

by Tan, Hong Qi, Ong, Hiok Hian, Kumaran, Arjunan Muthu, Tan, Tira J., Tan, Ryan Ying Cong, Lee, Ghislaine Su-Xin, Lim, Elaine Hsuen, Ng, Raymond, Yeo, Richard Ming Chert, Lim, Faye Lynette Tching Wei, Zhang, Zewen, Yang, Christina Shi Hui, Wong, Ru Xin, Ooi, Gideon Su Kai, Chee, Lester Hao Leong, Tan, Su Ming, Preetha, Madhukumar, Sim, Yirong, Tan, Veronique Kiak Mien, Yeong, Joe, Wong, Fuh Yong, Cai, Yiyu, Nei, Wen Long, JBCR, Ai3
Published 2022

A Randomized Phase 2 Trial of Nivolumab Versus Nivolumab-Ipilimumab Combination in EGFR-Mutant NSCLC

by Lai, Gillianne GY, Yeo, Jia Chi, Jain, Amit, Zhou, Siqin, Pang, Mengyuan, Alvarez, Jacob JS, Sim, Ngak Leng, Tan, Aaron C, Suteja, Lisda, Lim, Tze Wei, Guo, Yu Amanda, Shen, Meixin, Saw, Stephanie PL, Rohatgi, Neha, Yeong, Joe PS, Takano, Angela, Lim, Kiat Hon, Gogna, Apoorva, Too, Chow Wei, Da Zhuang, Kun, Tan, Wan Ling, Kanesvaran, Ravindran, Ng, Quan Sing, Ang, Mei Kim, Rajasekaran, Tanujaa, Wang, Lanying, Toh, Chee Keong, Lim, Wan-Teck, Tam, Wai Leong, Tan, Sze Huey, Skanderup, Anders MJ, Tan, Eng-Huat, Tan, Daniel SW
Published 2024

Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

by Nguyen, Phuong H. D., Wasser, Martin, Tan, Chong Teik, Lim, Chun Jye, Lai, Hannah L. H., Seow, Justine Jia Wen, DasGupta, Ramanuj, Phua, Cheryl Z. J., Ma, Siming, Yang, Jicheng, Sheena D/O Suthen, Tam, Wai Leong, Lim, Tony K. H., Yeong, Joe, Leow, Wei Qiang, Pang, Yin Huei, Soon, Gwyneth, Loh, Tracy Jiezhen, Wan, Wei Keat, Chan, Chung Yip, Cheow, Peng Chung, Toh, Han Chong, Kow, Alfred, Dan, Yock Young, Kam, Juinn Huar, Iyer, Shridhar, Madhavan, Krishnakumar, Chung, Alexander, Bonney, Glenn K., Goh, Brian K. P., Fu, Naiyang, Yu, Victor C., Zhai, Weiwei, Albani, Salvatore, Chow, Pierce K. H., Chew, Valerie
Published 2023

Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition

by Sundar, Raghav, Huang, Kie-Kyon, Kumar, Vikrant, Ramnarayanan, Kalpana, Demircioglu, Deniz, Her, Zhisheng, Ong, Xuewen, Isa, Zul Fazreen Bin Adam, Xing, Manjie, Tan, Angie Lay-Keng, Tai, David Wai Meng, Choo, Su Pin, Zhai, Weiwei, Lim, Jia Qi, Das Thakur, Meghna, Molinero, Luciana, Cha, Edward, Fasso, Marcella, Niger, Monica, Pietrantonio, Filippo, Lee, Jeeyun, Jeyasekharan, Anand D, Qamra, Aditi, Patnala, Radhika, Fabritius, Arne, De Simone, Mark, Yeong, Joe, Ng, Cedric Chuan Young, Rha, Sun Young, Narita, Yukiya, Muro, Kei, Guo, Yu Amanda, Skanderup, Anders Jacobsen, So, Jimmy Bok Yan, Yong, Wei Peng, Chen, Qingfeng, Goke, Jonathan, Tan, Patrick
Published 2022

Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities

by Chua, Khi Pin, Teng, Yvonne HF, Tan, Aaron C, Takano, Angela, Alvarez, Jacob JS, Nahar, Rahul, Rohatgi, Neha, Lai, Gillianne GY, Aung, Zaw Win, Yeong, Joe PS, Lim, Kiat Hon, Naeini, Marjan Mojtabavi, Kassam, Irfahan, Jain, Amit, Tan, Wan Ling, Gogna, Apoorva, Too, Chow Wei, Kanesvaran, Ravindran, Ng, Quan Sing, Ang, Mei Kim, Rajasekaran, Tanujaa, Anantham, Devanand, Phua, Ghee Chee, Tan, Bien Soo, Lee, Yin Yeng, Wang, Lanying, Teo, Audrey SM, Khng, Alexis Jiaying, Lim, Ming Jie, Suteja, Lisda, Toh, Chee Keong, Lim, Wan-Teck, Iyer, N Gopalakrishna, Tam, Wai Leong, Tan, Eng-Huat, Zhai, Weiwei, Hillmer, Axel M, Skanderup, Anders J, Tan, Daniel SW
Published 2024

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

by Lechner, Matt, Schartinger, Volker H., Steele, Christopher D., Nei, Wen Long, Ooft, Marc Lucas, Schreiber, Liesa-Marie, Pipinikas, Christodoulos P., Chung, Grace Tin-Yun, Chan, Yuk Yu, Wu, Feng, To, Ka-Fai, Tsang, Chi Man, Pearce, Wayne, Morelli, Daniele, Philpott, Martin, Masterson, Liam, Nibhani, Reshma, Wells, Graham, Bell, Christopher G., Koller, Julia, Delecluse, Susanne, Yip, Yim Ling, Liu, Jacklyn, Forde, Cillian T., Forster, Martin D., Jay, Amrita, Dudás, József, Krapp, Annika, Wan, Simon, Uprimny, Christian, Sprung, Susanne, Haybaeck, Johannes, Fenton, Tim R., Chester, Kerry, Thirlwell, Christina, Royle, Gary, Marafioti, Teresa, Gupta, Rajeev, Indrasari, Sagung Rai, Herdini, Camelia, Slim, Mohd Afiq Mohd, Indrawati, I., Sutton, Liam, Fles, Renske, Tan, Bing, Yeong, Joe, Jain, Amit, Han, Shuting, Wang, Haitao, Loke, Kelvin S. H., He, Wan, Xu, Ruilian, Jin, Hongtao, Cheng, Zhiqiang, Howard, David, Hwang, Peter H., Le, Quynh-Thu, Tay, Joshua K., West, Robert B., Tsao, Sai Wah, Meyer, Tim, Riechelmann, Herbert, Oppermann, Udo, Delecluse, Henri-Jacques, Willems, Stefan M., Chua, Melvin L. K., Busson, Pierre, Lo, Kwok Wai, Wollmann, Guido, Pillay, Nischalan, Vanhaesebroeck, Bart, Lund, Valerie J.
Published 2022