CLINICAL APPLICATION OF CANCER EXOME SEQUENCING

by HUANG KIE KYON
Published 2017

High efficacy of BAY 1187982, an FGFR2-ADC, in overcoming drug resistance in a diffuse type gastric cancer patient-derived xenograft model with acquired resistance to pan-FGFR inhi...

by Lau, Wen Min, Teng, Eileen, Huang, Kie Kyon, Tan, Jin Wei, Teh, Ming, Yong, Wei Peng, Sommer, Anette, Schatz, Christoph A, Tan, Patrick, Chan, Shing Leng, So, Jimmy
Published 2019

CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies

by Davies, Rebecca, Liu, Ling, Taotao, Sheng, Tuano, Natasha, Chaturvedi, Richa, Huang, Kie Kyon, Itman, Catherine, Mandoli, Amit, Qamra, Aditi, Hu, Changyuan, Powell, David, Daly, Roger J., Tan, Patrick, Rosenbluh, Joseph
Published 2022

Author Correction: CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies (Genome Biology, (2021), 22, 1, (47)...

by Davies, Rebecca, Liu, Ling, Taotao, Sheng, Tuano, Natasha, Chaturvedi, Richa, Huang, Kie Kyon, Itman, Catherine, Mandoli, Amit, Qamra, Aditi, Hu, Changyuan, Powell, David, Daly, Roger J., Tan, Patrick, Rosenbluh, Joseph
Published 2022

Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer

by Huang, Kie Kyon, Huang, Jiawen, Wu, Jeanie Kar Leng, Lee, Minghui, Tay, Su Ting, Kumar, Vikrant, Ramnarayanan, Kalpana, Padmanabhan, Nisha, Xu, Chang, Tan, Angie Lay Keng, Chan, Charlene, Kappei, Dennis, Göke, Jonathan, Tan, Patrick
Published 2022

Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3 beta

by Lau, Wen Min, Teng, Eileen, Huang, Kie Kyon, Tan, Jin Wei, Das, Kakoli, Zang, Zhijiang, Chia, Tania, Teh, Ming, Kono, Koji, Yong, Wei Peng, Shabbir, Asim, Tay, Amy, Phua, Niam Sin, Tan, Patrick, Chan, Shing Leng, So, Jimmy Bok Yan
Published 2021

DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia

by Krishnan, Vaidehi, Lim, Debbie Xiu En, Hoang, Phuong Mai, Srivastava, Supriya, Matsuo, Junichi, Huang, Kie Kyon, Zhu, Feng, Ho, Khek Yu, So, Jimmy Bok Yan, Khor, Christopher, Tsao, Stephen, Teh, Ming, Fock, Kwong Ming, Ang, Tiing Leong, Jeyasekharan, Anand D, Tan, Patrick, Yeoh, Khay-Guan, Ito, Yoshiaki
Published 2020

Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer

by Sheng, Taotao, Ho, Shamaine Wei Ting, Ooi, Wen Fong, Xu, Chang, Xing, Manjie, Padmanabhan, Nisha, Huang, Kie Kyon, Ma, Lijia, Ray, Mohana, Guo, Yu Amanda, Sim, Ngak Leng, Anene-Nzelu, Chukwuemeka George, Chang, Mei Mei, Razavi-Mohseni, Milad, Beer, Michael A, Foo, Roger Sik Yin, Sundar, Raghav, Chan, Yiong Huak, Tan, Angie Lay Keng, Ong, Xuewen, Skanderup, Anders Jacobsen, White, Kevin P, Jha, Sudhakar, Tan, Patrick
Published 2021

Chromatin rewiring by mismatch repair protein MSH2 alters cell adhesion pathways and sensitivity to BET inhibition in gastric cancer

by Nargund, Amrita M., Xu, Chang, Mandoli, Amit, Okabe, Atsushi, Chen, Gao Bin, Huang, Kie Kyon, Sheng, Taotao, Yao, Xiaosai, Teo, Jia Ming Nickolas, Sundar, Raghav, Kok, Yee Jiun, See, Yi Xiang, Xing, Manjie, Li, Zhimei, Yong, Chern Han, Anand, Aparna, Fazreen, A. I. Zul, Poon, Lai Fong, Ng, Michelle Shu Wen, Koh, Javier Yu Peng, Ooi, Wen Fong, Tay, Su Ting, Ong, Xuewen, Tan, Angie Lay Keng, Grabsch, Heike I., Fullwood, Melissa Jane, Teh, Tean Bin, Bi, Xuezhi, Kaneda, Atsushi, Li, Shang, Tan, Patrick
Published 2022

Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition

by Sundar, Raghav, Huang, Kie-Kyon, Kumar, Vikrant, Ramnarayanan, Kalpana, Demircioglu, Deniz, Her, Zhisheng, Ong, Xuewen, Isa, Zul Fazreen Bin Adam, Xing, Manjie, Tan, Angie Lay-Keng, Tai, David Wai Meng, Choo, Su Pin, Zhai, Weiwei, Lim, Jia Qi, Das Thakur, Meghna, Molinero, Luciana, Cha, Edward, Fasso, Marcella, Niger, Monica, Pietrantonio, Filippo, Lee, Jeeyun, Jeyasekharan, Anand D, Qamra, Aditi, Patnala, Radhika, Fabritius, Arne, De Simone, Mark, Yeong, Joe, Ng, Cedric Chuan Young, Rha, Sun Young, Narita, Yukiya, Muro, Kei, Guo, Yu Amanda, Skanderup, Anders Jacobsen, So, Jimmy Bok Yan, Yong, Wei Peng, Chen, Qingfeng, Goke, Jonathan, Tan, Patrick
Published 2022