Chromatin rewiring by mismatch repair protein MSH2 alters cell adhesion pathways and sensitivity to BET inhibition in gastric cancer

• Main Authors: Nargund, Amrita M., Xu, Chang, Mandoli, Amit, Okabe, Atsushi, Chen, Gao Bin, Huang, Kie Kyon, Sheng, Taotao, Yao, Xiaosai, Teo, Jia Ming Nickolas, Sundar, Raghav, Kok, Yee Jiun, See, Yi Xiang, Xing, Manjie, Li, Zhimei, Yong, Chern Han, Anand, Aparna, Fazreen, A. I. Zul, Poon, Lai Fong, Ng, Michelle Shu Wen, Koh, Javier Yu Peng, Ooi, Wen Fong, Tay, Su Ting, Ong, Xuewen, Tan, Angie Lay Keng, Grabsch, Heike I., Fullwood, Melissa Jane, Teh, Tean Bin, Bi, Xuezhi, Kaneda, Atsushi, Li, Shang, Tan, Patrick
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Mutations; Protein
• Online Access: https://hdl.handle.net/10356/163560
• Institution: Nanyang Technological University

Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) in multiple cancers. Here, we discovered that besides its well-established role in DNA repair, MSH2 exerts a novel epigenomic function in gastric cancer. Unbiased CRISPR-based mass spectrometry combined...