Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides

• Main Authors: Liu, Rui-Hua, Shan, Qi-Chao, Gao, Ya, Loh, Teck-Peng, Hu, Xu-Hong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Enamides; Sulfoxonium Ylides
• Online Access: https://hdl.handle.net/10356/161719
• Institution: Nanyang Technological University

Disclosed herein is an efficient Ag-catalyzed [4 + 1] heteroannulation reaction of enamides with α-carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant t...