In vivo liquid-liquid phase separation protects amyloidogenic and aggregation-prone peptides during overexpression in Escherichia coli

Studying pathogenic effects of amyloids requires homogeneous amyloidogenic peptide samples. Recombinant production of these peptides is challenging due to their susceptibility to aggregation and chemical modifications. Thus, chemical synthesis is primarily used to produce amyloidogenic peptides suit...

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Bibliographic Details
Main Authors: Gabryelczyk, Bartosz, Alag, Reema, Philips, Margaret, Low, Kimberly, Venkatraman, Anandalakshmi, Kannaian, Bhuvaneswari, Shi, Xiangyan, Linder, Markus, Pervushin, Konstantin, Miserez, Ali
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/162100
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Institution: Nanyang Technological University
Language: English