Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake

• Main Authors: Kwek, Germain, Lingesh, Shonya, Chowdhury, Sayba Zafrin, Xing, Bengang
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Bioengineering; Science::Chemistry; Glucose Uptake; Molecular Crowding
• Online Access: https://hdl.handle.net/10356/162149
• Institution: Nanyang Technological University

An unconventional environment-responsive molecular crowding via specific binding between small molecule peptide inhibitor derivatives and an overexpressed tumour enzyme has been developed. Assemblies of such short peptides selectively localize on tumour surfaces and exhibited unique functions in dis...