Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake

Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake

An unconventional environment-responsive molecular crowding via specific binding between small molecule peptide inhibitor derivatives and an overexpressed tumour enzyme has been developed. Assemblies of such short peptides selectively localize on tumour surfaces and exhibited unique functions in dis...

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Main Authors: Kwek, Germain, Lingesh, Shonya, Chowdhury, Sayba Zafrin, Xing, Bengang
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2022
Subjects:
Engineering::Bioengineering
Science::Chemistry
Glucose Uptake
Molecular Crowding
Online Access:https://hdl.handle.net/10356/162149
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1621492022-10-05T08:22:40Z Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake Kwek, Germain Lingesh, Shonya Chowdhury, Sayba Zafrin Xing, Bengang School of Chemical and Biomedical Engineering School of Physical and Mathematical Sciences Engineering::Bioengineering Science::Chemistry Glucose Uptake Molecular Crowding An unconventional environment-responsive molecular crowding via specific binding between small molecule peptide inhibitor derivatives and an overexpressed tumour enzyme has been developed. Assemblies of such short peptides selectively localize on tumour surfaces and exhibited unique functions in disrupting hyperactivated glucose uptake, providing novel insights towards strategic tumour treatment. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University The authors acknowledge financial support from the National Natural Science Foundation of China (NSFC) (No. 51929201), Tier 1 RG6/20 and A*Star SERC A1983c0028 (M4070319), and A20E5c0090 from Nanyang Technological University (NTU). 2022-10-05T08:22:40Z 2022-10-05T08:22:40Z 2022 Journal Article Kwek, G., Lingesh, S., Chowdhury, S. Z. & Xing, B. (2022). Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake. Chemical Communications, 58(9), 1350-1353. https://dx.doi.org/10.1039/d1cc06049j 1359-7345 https://hdl.handle.net/10356/162149 10.1039/d1cc06049j 34986211 2-s2.0-85123901507 9 58 1350 1353 en A1983c0028 (M4070319) A20E5c0090 Chemical Communications © 2022 The Royal Society of Chemistry. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Bioengineering
Science::Chemistry
Glucose Uptake
Molecular Crowding
spellingShingle Engineering::Bioengineering
Science::Chemistry
Glucose Uptake
Molecular Crowding
Kwek, Germain
Lingesh, Shonya
Chowdhury, Sayba Zafrin
Xing, Bengang
Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake
description An unconventional environment-responsive molecular crowding via specific binding between small molecule peptide inhibitor derivatives and an overexpressed tumour enzyme has been developed. Assemblies of such short peptides selectively localize on tumour surfaces and exhibited unique functions in disrupting hyperactivated glucose uptake, providing novel insights towards strategic tumour treatment.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Kwek, Germain
Lingesh, Shonya
Chowdhury, Sayba Zafrin
Xing, Bengang
format Article
author Kwek, Germain
Lingesh, Shonya
Chowdhury, Sayba Zafrin
Xing, Bengang
author_sort Kwek, Germain
title Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake
title_short Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake
title_full Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake
title_fullStr Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake
title_full_unstemmed Tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake
title_sort tumour enzyme affinity mediated peptide molecular crowding for targeted disruption of hyperactivated glucose uptake
publishDate 2022
url https://hdl.handle.net/10356/162149
_version_ 1746219682234368000

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