Selective recognition of phosphatidylinositol phosphate receptors by C‑terminal tail of mitotic kinesin-like protein 2 (MKlp2)

• Main Authors: Tae, Hyunhyuk, Park, Soohyun, Kim, Seong-Oh, Yorulmaz, Saziye, Cho, Nam-Joon
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Maritime studies; Binding Energy; Cell Membranes
• Online Access: https://hdl.handle.net/10356/162153
• Institution: Nanyang Technological University

The mitotic kinesin-like protein 2 (MKlp2) plays a key role in the proper completion of cytokinetic abscission. Specifically, the C-terminal tail of MKlp2 (CTM peptides) offers a stable tethering on the plasma membrane and microtubule cytoskeleton in the midbody during abscission. However, little is...