Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein

• Main Authors: Park, H.-W, Ma, Z, Zhu, H, Jiang, S, Robinson, R.C, Endow, S.A
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: 5-methyl-N-(1-oxo-1-(pyrrolidin-3-ylamino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide; alanine; Drosophila protein; enzyme inhibitor; KIF1C protein, human; Kifc3 protein, human; kinesin; ncd protein, Drosophila; protein binding; pyridine derivative; analogs and derivatives; antagonists and inhibitors; binding site; chemistry; human; metabolism; molecular model; protein conformation; X ray crystallography; Alanine; Binding Sites; Crystallography, X-Ray; Drosophila Proteins; Enzyme Inhibitors; Humans; Kinesin; Models, Molecular; Protein Binding; Protein Conformation; Pyridines
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174388
• Institution: National University of Singapore

10.1038/s41598-017-14754-6