Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein

10.1038/s41598-017-14754-6

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Main Authors:	Park, H.-W, Ma, Z, Zhu, H, Jiang, S, Robinson, R.C, Endow, S.A
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	5-methyl-N-(1-oxo-1-(pyrrolidin-3-ylamino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide alanine Drosophila protein enzyme inhibitor KIF1C protein, human Kifc3 protein, human kinesin ncd protein, Drosophila protein binding pyridine derivative analogs and derivatives antagonists and inhibitors binding site chemistry human metabolism molecular model protein conformation X ray crystallography Alanine Binding Sites Crystallography, X-Ray Drosophila Proteins Enzyme Inhibitors Humans Kinesin Models, Molecular Protein Binding Protein Conformation Pyridines
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/174388
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1743882024-11-12T01:39:11Z Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein Park, H.-W Ma, Z Zhu, H Jiang, S Robinson, R.C Endow, S.A DUKE-NUS MEDICAL SCHOOL BIOCHEMISTRY 5-methyl-N-(1-oxo-1-(pyrrolidin-3-ylamino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide alanine Drosophila protein enzyme inhibitor KIF1C protein, human Kifc3 protein, human kinesin ncd protein, Drosophila protein binding pyridine derivative analogs and derivatives antagonists and inhibitors binding site chemistry human metabolism molecular model protein conformation X ray crystallography Alanine Binding Sites Crystallography, X-Ray Drosophila Proteins Enzyme Inhibitors Humans Kinesin Models, Molecular Protein Binding Protein Conformation Pyridines 10.1038/s41598-017-14754-6 Scientific Reports 7 1 15121 2020-09-04T03:31:26Z 2020-09-04T03:31:26Z 2017 Article Park, H.-W, Ma, Z, Zhu, H, Jiang, S, Robinson, R.C, Endow, S.A (2017). Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein. Scientific Reports 7 (1) : 15121. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-14754-6 2045-2322 https://scholarbank.nus.edu.sg/handle/10635/174388 Nature Publishing Group Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	5-methyl-N-(1-oxo-1-(pyrrolidin-3-ylamino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide alanine Drosophila protein enzyme inhibitor KIF1C protein, human Kifc3 protein, human kinesin ncd protein, Drosophila protein binding pyridine derivative analogs and derivatives antagonists and inhibitors binding site chemistry human metabolism molecular model protein conformation X ray crystallography Alanine Binding Sites Crystallography, X-Ray Drosophila Proteins Enzyme Inhibitors Humans Kinesin Models, Molecular Protein Binding Protein Conformation Pyridines
spellingShingle	5-methyl-N-(1-oxo-1-(pyrrolidin-3-ylamino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide alanine Drosophila protein enzyme inhibitor KIF1C protein, human Kifc3 protein, human kinesin ncd protein, Drosophila protein binding pyridine derivative analogs and derivatives antagonists and inhibitors binding site chemistry human metabolism molecular model protein conformation X ray crystallography Alanine Binding Sites Crystallography, X-Ray Drosophila Proteins Enzyme Inhibitors Humans Kinesin Models, Molecular Protein Binding Protein Conformation Pyridines Park, H.-W Ma, Z Zhu, H Jiang, S Robinson, R.C Endow, S.A Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein
description	10.1038/s41598-017-14754-6
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Park, H.-W Ma, Z Zhu, H Jiang, S Robinson, R.C Endow, S.A
format	Article
author	Park, H.-W Ma, Z Zhu, H Jiang, S Robinson, R.C Endow, S.A
author_sort	Park, H.-W
title	Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein
title_short	Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein
title_full	Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein
title_fullStr	Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein
title_full_unstemmed	Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein
title_sort	structural basis of small molecule atpase inhibition of a human mitotic kinesin motor protein
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/174388
_version_	1821200888380784640

Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein

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