Persistent spectral based ensemble learning (PerSpect-EL) for protein-protein binding affinity prediction

• Main Authors: Wee, Junjie, Xia, Kelin
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Mathematics; Protein–Protein Interaction; Hodge Laplacian
• Online Access: https://hdl.handle.net/10356/162232
• Institution: Nanyang Technological University

Protein-protein interactions (PPIs) play a significant role in nearly all cellular and biological activities. Data-driven machine learning models have demonstrated great power in PPIs. However, the design of efficient molecular featurization poses a great challenge for all learning models for PPIs....