Scar prevention through topical delivery of gelatin-tyramine-siSPARC nanoplex loaded in dissolvable hyaluronic acid microneedle patch across skin barrier

Scar prevention through topical delivery of gelatin-tyramine-siSPARC nanoplex loaded in dissolvable hyaluronic acid microneedle patch across skin barrier

Currently, there is no effective method to prevent the formation of hypertrophic scars and keloids, which can cause severe physical and psychological burdens to patients. Secreted protein acidic and cysteine-rich (SPARC) is involved in wound fibrosis by modulating fibroblast functions, causing exces...

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Bibliographic Details
Main Authors: Chun, Yong Yao, Tan, William Wei Ren, Vos, Marcus Ivan Gerard, Chan, Wen Kiat, Tey, Hong Liang, Tan, Nguan Soon, Tan, Timothy Thatt Yang
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2022
Subjects:
Science::Medicine
Microneedle Patches
Scar Formation
Online Access:https://hdl.handle.net/10356/162361
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/162361

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